Shulkes A, Lewis S J, Jarrott B
Department of Surgery and Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australia.
Neuropeptides. 1989 Jul;14(1):59-64. doi: 10.1016/0143-4179(89)90035-8.
The regional brain and spinal cord concentrations of cholecystokinin-octapeptide (CCK-8) were measured in age-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats. The relative order of distribution of CCK-8 in the WKY strain was hippocampus (20.5 +/- 1.3 pmol/g) greater than cortex greater than striatum = hypothalamus greater than midbrain = thalamus greater than spinal cord greater than medulla oblongata/pons (MO/P, 1.6 +/- 0.2 pmol/g) whereas in the SH strain this order was hippocampus (12.9 +/- 0.8 pmol/g) greater than cortex = striatum greater than hypothalamus greater than midbrain greater than thalamus = spinal cord greater than MO/P (1.4 +/- 0.2 pmol/g). The concentrations of CCK-8 in the cerebellum were at the level of assay sensitivity (0.5 pmol/g in both strains). In comparison to the WKY rats, the SH strain had significantly lower levels of CCK-8 in the hippocampus (-37%), cortex (-28%), spinal cord (-23%) and pituitary (-57%). The lowered levels of CCK-8 in the brain of the SH rat may be causally related to, or result from, the cardiovascular, behavioural or morphological abnormalities of this strain.
在年龄匹配的正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压（SH）大鼠中，测量了胆囊收缩素八肽（CCK-8）在脑和脊髓各区域的浓度。CCK-8在WKY大鼠中的分布相对顺序为海马体（20.5±1.3 pmol/g）＞皮质＞纹状体 = 下丘脑＞中脑 = 丘脑＞脊髓＞延髓/脑桥（MO/P，1.6±0.2 pmol/g），而在SH大鼠中，该顺序为海马体（12.9±0.8 pmol/g）＞皮质 = 纹状体＞下丘脑＞中脑＞丘脑 = 脊髓＞MO/P（1.4±0.2 pmol/g）。两种品系大鼠小脑内CCK-8的浓度均处于检测灵敏度水平（均为0.5 pmol/g）。与WKY大鼠相比，SH大鼠海马体（-37%）、皮质（-28%）、脊髓（-23%）和垂体（-57%）中的CCK-8水平显著降低。SH大鼠脑中CCK-8水平降低可能与该品系大鼠的心血管、行为或形态异常存在因果关系，或者是这些异常的结果。
