Lewis S J, Shulkes A, Jarrott B
Brain Res. 1986 Dec 3;399(1):173-7. doi: 10.1016/0006-8993(86)90614-1.
The regional brain and spinal cord concentrations of vasoactive intestinal polypeptide immunoreactivity (VIP) were measured in age-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats. The relative order of distribution of VIP in the WKY strain was cortex (44 pmol/g) greater than hippocampus = striatum greater than midbrain = hypothalamus greater than medulla oblongata/pons = lumbar spinal cord (SC) greater than cervical SC greater than thoracic SC (2.5 pmol/g) whereas in the SH strain this order was cortex (35 pmol/g) greater than striatum = midbrain greater than hippocampus = hypothalamus greater than medulla oblongata/pons = lumbar SC greater than cervical SC greater than thoracic SC (1 pmol/g). The VIP concentrations of the thalamus, cerebellum and pituitary were at the level of assay sensitivity (0.5 pmol/g) in both strains. In comparison to the WKY, the SH rats had significantly lower VIP levels in the hippocampus (-42%) and cervical (-46%) and thoracic (-56%) spinal cord but significantly higher levels in the midbrain (+64%).
在年龄匹配的正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压（SH）大鼠中，测量了血管活性肠多肽免疫反应性（VIP）在脑和脊髓各区域的浓度。VIP在WKY品系中的分布相对顺序为：皮层（44 pmol/g）大于海马体 = 纹状体大于中脑 = 下丘脑大于延髓/脑桥 = 腰段脊髓（SC）大于颈段SC大于胸段SC（2.5 pmol/g），而在SH品系中，此顺序为：皮层（35 pmol/g）大于纹状体 = 中脑大于海马体 = 下丘脑大于延髓/脑桥 = 腰段SC大于颈段SC大于胸段SC（1 pmol/g）。在两个品系中，丘脑、小脑和垂体的VIP浓度均处于检测灵敏度水平（0.5 pmol/g）。与WKY相比，SH大鼠海马体中的VIP水平显著降低（-42%），颈段（-46%）和胸段（-56%）脊髓中的VIP水平也显著降低，但中脑中的VIP水平显著升高（+64%）。
