Azarpazhooh Mahmoud Reza, Kazemi-Bajestani Seyyed Mohammad Reza, Esmaeili Habib, Vedadian Payam, Ebrahimi Mahmoud, Parizadeh Seyyed Mohammad Reza, Heidari-Bakavoli Ali Reza, Moohebati Mohsen, Safarian Mohammad, Mokhber Naghmeh, Nematy Mohsen, Mazidi Mohsen, Ferns Gorden A, Ghayour-Mehrabani Majid
Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Int J Prev Med. 2014 Nov;5(11):1412-21.
Carotid ultrasound appears to be useful in the assessment of cardiovascular risk. In this study, we have assessed the carotid intima-media thickness (CIMT) in a group of individuals without a history of cardiovascular events.
A sample of 431subjects (189 [43.9%] males and 242 [56.1%] females) was obtained from an urban population using a stratified-cluster method in Mashhad stroke and heart atherosclerosis disorder study. None of the subjects had a history of the cardiovascular event. Carotid artery duplex ultrasound was used to determine the CIMT in all subjects, and to identify those with an abnormal value (CIMT [+]; i.e., CIMT ≥ 0.8 mm). Dietary intake of participants was assessed using a questionnaire for 24-h dietary recall. The relationship between anthropometric, biochemical and dietary data and CIMT were assessed.
The mean age of subjects was 48.7 ± 8.0 years. Of the 431 patients, 118 (27.4%) were found to be CIMT (+). Of the cardiovascular parameters assessed, only age (odds ratio [OR] [95% confidence interval (CI)], 1.11 [0.56-4.34]; P < 0.01) and male gender (OR [95% CI], 1.14 [0.63-2.23]; P < 0.05) were significant independent predictors of ultrasound defined CIMT. Crude and total energy adjusted intake were not associated with the presence of CIMT (+).
It appears that within a relatively young Iranian population of individuals without a history of cardiovascular event, the presence of CIMT (+) defined by duplex ultrasound cut-off value of ≥0.8 mm, did not associate with several modifiable cardiovascular risk factors or measures of dietary intake.
颈动脉超声似乎有助于评估心血管风险。在本研究中，我们评估了一组无心血管事件病史个体的颈动脉内膜中层厚度（CIMT）。
在马什哈德中风与心脏动脉粥样硬化疾病研究中，采用分层整群抽样法从城市人群中选取了431名受试者（189名[43.9%]男性和242名[56.1%]女性）。所有受试者均无心血管事件病史。使用颈动脉双功能超声测定所有受试者的CIMT，并识别CIMT值异常者（CIMT[+]，即CIMT≥0.8mm）。通过24小时饮食回忆问卷评估参与者的饮食摄入量。评估人体测量学、生化和饮食数据与CIMT之间的关系。
受试者的平均年龄为48.7±8.0岁。在431例患者中，发现118例（27.4%）CIMT为（+）。在评估的心血管参数中，只有年龄（优势比[OR][95%置信区间（CI）]，1.11[0.56 - 4.34]；P<0.01）和男性性别（OR[95%CI]，1.14[0.63 - 2.23]；P<0.05）是超声定义的CIMT的显著独立预测因素。粗略和总能量调整摄入量与CIMT（+）的存在无关。
在相对年轻、无心血管事件病史的伊朗人群中，由双功能超声截断值≥0.8mm定义的CIMT（+）似乎与几种可改变的心血管危险因素或饮食摄入量指标无关。
