Sandi C, Borrell J, Guaza C
Cajal Institute, Department of Psychobiology, C.S.I.C., Madrid, Spain.
Life Sci. 1990;46(16):1119-29. doi: 10.1016/0024-3205(90)90448-z.
Using a paradigm by which rats forced to drink a weak ethanol solution (2.5% w/v) (conditioning session) develop ethanol preference in consecutive retention testing days, the effects of the administration of the kappa opioid antagonist MR-2266-BS, prior to or after the forced ethanol session, were studied. Pre-conditioning subcutaneous (s.c.) administration of 1 mg/kg of MR-2266-BS induced a decrease in subsequent ethanol consumption without significantly modifying the acquisition of ethanol preference. Post-conditioning administration of MR-2266-BS (0.1, 1, 5 or 10 mg/kg) induced both a dose-dependent reduction in ethanol consumption and in preference throughout the three following days. The results of the present study provide further support of the involvement of kappa-type opioids on drinking behavior, and suggest that kappa receptors may be involved in the consumption and development of preference to ethanol.
采用一种实验范式，即强迫大鼠饮用低浓度乙醇溶液（2.5% w/v）（条件训练阶段），在连续的保留测试日中大鼠会产生乙醇偏好，研究了在强迫乙醇摄入阶段之前或之后给予κ阿片受体拮抗剂MR-2266-BS的效果。在条件训练前皮下注射（s.c.）1 mg/kg的MR-2266-BS会导致随后乙醇摄入量减少，但不会显著改变乙醇偏好的形成。在条件训练后给予MR-2266-BS（0.1、1、5或10 mg/kg），在接下来的三天中会导致乙醇摄入量和偏好呈剂量依赖性降低。本研究结果进一步支持了κ型阿片类物质参与饮酒行为，并表明κ受体可能参与乙醇的摄入和偏好形成。
