Sandi C, Borrell J, Guaza C
Department of Psychobiology, Cajal Institute, CSIC, Madrid, Spain.
Pharmacol Biochem Behav. 1988 Jan;29(1):39-43. doi: 10.1016/0091-3057(88)90270-5.
The effect of subcutaneous naloxone administration on the consumption of a weak ethanol solution in rats on the three consecutive days (testing days) was investigated using a behavioral paradigm which includes a first forced ethanol exposure (conditioning day) followed by a two-bottle ethanol/water choice procedure. Besides reducing fluid intake, naloxone treatment prior to forced ethanol exposure interferes with the acquisition of ethanol preference. Post-conditioning naloxone administration fails to affect ethanol preference. Administration of naloxone prior to the first testing session induces a reduction on total fluid intake, at the day of treatment; a decrease on ethanol preference throughout the three consecutive testing days is also observed with the higher dose of the antagonist (5 mg/kg). An involvement of endogenous opioids in ethanol consumption is suggested through the modulation of alcohol reinforcement or the affective quality of the gustatory cue.
采用一种行为模式研究皮下注射纳洛酮对大鼠连续三天（测试日）饮用低浓度乙醇溶液的影响，该行为模式包括首次强制乙醇暴露（适应日），随后是两瓶乙醇/水选择程序。除了减少液体摄入量外，在强制乙醇暴露前给予纳洛酮治疗会干扰乙醇偏好的形成。适应后给予纳洛酮对乙醇偏好没有影响。在第一次测试前给予纳洛酮会导致治疗当天总液体摄入量减少；使用较高剂量的拮抗剂（5毫克/千克）时，在连续三天的测试中乙醇偏好也会降低。内源性阿片类物质通过调节酒精强化作用或味觉线索的情感性质参与乙醇消耗。
