编码人c-src蛋白氨基末端区域的DNA序列：src型激酶癌基因间序列差异的意义
DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.
作者信息
Tanaka A, Gibbs C P, Arthur R R, Anderson S K, Kung H J, Fujita D J
出版信息
Mol Cell Biol. 1987 May;7(5):1978-83. doi: 10.1128/mcb.7.5.1978-1983.1987.
Abstract
We sequenced the 5'-coding region of the human c-src gene, exons 2 through 5, corresponding to one-third of the human c-src protein consisting of 536 amino acids. Sequence analysis of the src type of protein kinases revealed that the amino-terminal region encoded by exon 2 contains sequences specific for the src proteins and raised the possibility that this region is involved in the recognition of a src-specific substrate(s) or receptor(s).
摘要
我们对人类c-src基因的5'-编码区（外显子2至5）进行了测序，该区域对应于由536个氨基酸组成的人类c-src蛋白的三分之一。src型蛋白激酶的序列分析表明，外显子2编码的氨基末端区域包含src蛋白特有的序列，并增加了该区域参与识别src特异性底物或受体的可能性。
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