Heidl M, Scholz H
Klinischer Bereich, Instituts für Infektionskrankheiten im Kindesalter, Klinikum Berlin-Buch.
Padiatr Grenzgeb. 1990;29(1):31-6.
Basing of a review of the world literature the problems of the live attenuated varicella vaccine are presented. The vaccine is well tolerated and immunogenic. Side effects are unimportant. The vaccination is associated with a decrease of the chickenpox attack rate following an intensive exposure to varicella-zoster virus conferring about 80% protection in immunocompromised children over a period of 3-5 years. The vaccination provide an excellent protection against severe varicella in children with acute lymphocytic leukemia who remain on remission as well as in children with solid tumors. The incidence rate of zoster following vaccination is not higher than following natural varicella infection.
基于对世界文献的综述，介绍了减毒活水痘疫苗的相关问题。该疫苗耐受性良好且具有免疫原性。副作用并不严重。接种疫苗与在密集接触水痘-带状疱疹病毒后水痘发病率的降低相关，在3至5年的时间里为免疫功能低下的儿童提供约80%的保护。接种疫苗能为处于缓解期的急性淋巴细胞白血病儿童以及实体瘤儿童提供出色的严重水痘预防保护。接种疫苗后带状疱疹的发病率不高于自然感染水痘后的发病率。
