Jules Gonin Eye Hospital, Lausanne University, Lausanne, Switzerland.
Br J Ophthalmol. 2012 Mar;96(3):337-40. doi: 10.1136/bjophthalmol-2011-300051. Epub 2011 May 23.
Extension of retinoblastoma cells into the posterior chamber is a criterion for group E according to the international classification of intraocular retinoblastoma. Currently, the anterior extension of retinoblastoma is based on the presence of tumour cells in the anterior chamber assessed by biomicroscopy.
To determine the value of ultrasound biomicroscopy (UBM) in the assessment of posterior chamber involvement in advanced retinoblastoma.
Retrospective review of all retinoblastoma cases enucleated at the Jules Gonin Eye Hospital from January 1996 to December 2009 for which UBM (35 MHz) evaluation was available. The patients' records were reviewed for patient and tumour features and histopathological findings. UBM findings were compared with histopathological features.
UBM documentation was available in 31 cases. Retinoblastoma was detected by UBM in the posterior chamber in 18 cases and was absent in 13 cases while histopathological analysis demonstrated its presence in the posterior chamber in 22 cases and its absence in 9 cases. Among the 18 UBM-positive cases, 7 had biomicroscopic detectable involvement of the anterior chamber. There was a significant correlation between echodensities consistent with retinoblastoma on UBM in the posterior chamber and histopathological tumorous involvement of the posterior chamber (p=0.0001). The sensitivity of UBM in the assessment of posterior chamber invasion by retinoblastoma was 81% and the specificity was 100%.
In selected cases of advanced retinoblastoma, UBM appears to represent a valuable tool in the precise evaluation of anterior extension of disease, with good sensitivity and specificity for the assessment of posterior chamber involvement. UBM may provide useful criteria governing the indication for enucleation.
根据国际眼内视网膜母细胞瘤分类，视网膜母细胞瘤细胞延伸至后房是 E 组的标准。目前，视网膜母细胞瘤的前向延伸是基于前房内肿瘤细胞的存在，通过生物显微镜评估。
确定超声生物显微镜（UBM）在评估晚期视网膜母细胞瘤后房受累中的价值。
回顾性分析 1996 年 1 月至 2009 年 12 月在 Jules Gonin 眼科医院行眼球摘除术的所有视网膜母细胞瘤病例，这些病例均有 UBM（35MHz）评估。回顾患者和肿瘤特征以及组织病理学发现的记录。将 UBM 结果与组织病理学特征进行比较。
31 例病例有 UBM 记录。UBM 在 18 例病例中检测到后房内的视网膜母细胞瘤，而在 13 例病例中则没有，而组织病理学分析显示后房内存在 22 例，不存在 9 例。在 18 例 UBM 阳性病例中，有 7 例前房有可检测到的生物显微镜受累。UBM 在后房内回声密度与组织病理学肿瘤性后房受累之间存在显著相关性（p=0.0001）。UBM 评估视网膜母细胞瘤后房侵犯的敏感性为 81%，特异性为 100%。
在某些晚期视网膜母细胞瘤病例中，UBM 似乎是评估疾病前向延伸的一种有价值的工具，具有良好的敏感性和特异性，可用于评估后房受累。UBM 可能为眼球摘除提供有用的指征。
