Hassan H T, Rees J K
Department of Haematological Medicine, University of Cambridge Clinical School, Cambridge, UK.
Oncology. 1990;47(5):439-42. doi: 10.1159/000226865.
The relation between age and the cytological and cytochemical features of blast cell differentiation in 211 patients with primary acute myeloid leukaemia (AML) was investigated. Five cytological and cytochemical features of blast cell differentiation-the presence of Auer rods, the presence of granules, low nuclear/cytoplasmic ratio, Sudan black positivity and the maturation index-were studied in bone marrow smears of each AML patient. The results showed significantly more AML cases with both cytological and cytochemical features of blast cell differentiation in young patients (less than 60 years old) than in elderly patients (greater than 60 years old). These findings support the existence of two forms of primary AML: one more frequently detected in younger patients with more differentiated blast cells and the second with less differentiated blast cells mainly found in elderly patients.
对211例原发性急性髓系白血病（AML）患者的年龄与原始细胞分化的细胞学和细胞化学特征之间的关系进行了研究。在每位AML患者的骨髓涂片中研究了原始细胞分化的五项细胞学和细胞化学特征——奥氏小体的存在、颗粒的存在、低核/质比、苏丹黑阳性以及成熟指数。结果显示，年轻患者（小于60岁）中具有原始细胞分化的细胞学和细胞化学特征的AML病例明显多于老年患者（大于60岁）。这些发现支持存在两种形式的原发性AML：一种在较年轻患者中更常检测到，其原始细胞分化程度更高；另一种原始细胞分化程度较低，主要见于老年患者。
