Khaliq Waseem, Cheripalli Praveen, Tangella Krishnarao
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA.
South Med J. 2011 May;104(5):348-50. doi: 10.1097/SMJ.0b013e31821427db.
Tumor-induced osteomalacia is a rare acquired condition characterized by phosphaturia, hypophosphatemia and osteomalacia. We report an unusual presentation in a 15-year-old healthy male with a two-week history of cough and chest pain. The chest radiograph showed right middle lobe opacity and chest CT revealed a mass in the extra pleural space. A biopsy showed chondro-myxoidstroma with osteoid formation. Diagnosis was confirmed with the above findings and hypophosphatemia. The patient's symptoms resolved after complete surgical excision of the mass. Tumor-induced osteomalacia, although a rare disorder, can be a diagnostic challenge, especially in patients presenting with atypical symptoms.
肿瘤诱导的骨软化症是一种罕见的后天性疾病，其特征为磷酸盐尿、低磷血症和骨软化症。我们报告了一名15岁健康男性的不寻常病例，他有两周的咳嗽和胸痛病史。胸部X光片显示右中叶有不透明区，胸部CT显示胸膜外间隙有一个肿块。活检显示为软骨黏液样基质并伴有类骨质形成。根据上述发现及低磷血症确诊。肿块完全手术切除后患者症状缓解。肿瘤诱导的骨软化症虽然是一种罕见疾病，但可能是一个诊断难题，尤其是在表现为非典型症状的患者中。
