School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332-0356, USA.
Med Sci Sports Exerc. 2011 Dec;43(12):2396-404. doi: 10.1249/MSS.0b013e31822495a7.
Quercetin is a dietary flavonoid purported to improve human endurance exercise capacity. However, published findings are mixed.
The study's purpose was to perform a systematic review of the literature and meta-analysis to examine whether quercetin ingestion increases endurance exercise capacity.
A search of the literature was conducted using the key words quercetin, performance, exercise, endurance, and aerobic capacity. Eleven studies were identified as meeting the inclusion criteria providing data on 254 human subjects. Across all studies, subject presupplementation VO(2max) ranged from 41 to 64 mL·kg(-1)·min(-1) (median = 46), and median treatment duration was 11 d with a median dosage of 1000 mg·d(-1). Effect sizes (ES) were calculated as the standardized mean difference, and meta-analyses were completed using a random-effects model.
The ES calculated for all studies combining VO(2max) and endurance performance measures indicates a significant effect favoring quercetin over placebo (ES = 0.15, P = 0.021, 95% confidence interval = 0.02-0.27), but the magnitude of effect is considered between trivial and small, equating to a ∼2% [corrected] improvement of quercetin over placebo. Using a subgroup meta-analysis comparing quercetin's effect on endurance exercise performance versus VO(2max), no significant difference was found (P = 0.69). Meta-regression of study ES relative to subjects' fitness level or plasma quercetin concentration achieved by supplementation was also not significant.
On average, quercetin provides a statistically significant benefit in human endurance exercise capacity (VO(2max) and endurance exercise performance), but the effect is between trivial and small. Experimental factors that explain the between-study variation remain to be elucidated.
槲皮素是一种饮食类黄酮，据称可提高人类耐力运动能力。然而，已发表的研究结果不一。
本研究旨在对文献进行系统评价和荟萃分析，以检验槲皮素摄入是否能提高耐力运动能力。
使用关键词槲皮素、表现、运动、耐力和有氧能力对文献进行搜索。确定了 11 项符合纳入标准的研究，这些研究提供了 254 名人体受试者的数据。在所有研究中，受试者预补充 VO2max 范围为 41 至 64 mL·kg-1·min-1（中位数= 46），治疗时间中位数为 11 天，剂量中位数为 1000 mg·d-1。效应大小（ES）计算为标准化均数差，使用随机效应模型进行荟萃分析。
综合所有研究的 VO2max 和耐力表现指标计算的 ES 表明，槲皮素相对于安慰剂具有显著的效果（ES=0.15，P=0.021，95%置信区间为 0.02-0.27），但效果大小被认为介于微不足道和小之间，相当于槲皮素比安慰剂提高约 2%[校正]。使用亚组荟萃分析比较槲皮素对耐力运动表现与 VO2max 的影响，未发现显著差异（P=0.69）。也未发现研究 ES 相对于受试者的健康水平或补充后血浆槲皮素浓度的荟萃回归具有统计学意义。
平均而言，槲皮素对人体耐力运动能力（VO2max 和耐力运动表现）具有统计学显著的益处，但效果介于微不足道和小之间。解释研究间差异的实验因素仍有待阐明。
