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黄酮类化合物对有或无肌肉减少症的中老年人骨骼肌质量、力量和身体机能的影响：一项随机对照试验的荟萃分析

Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials.

作者信息

Li Yuzhuo, Liu Yun, Tan Rongshao, Liu Yan

机构信息

Department of Nephrology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.

Guangzhou Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.

出版信息

Front Nutr. 2022 Oct 10;9:1013449. doi: 10.3389/fnut.2022.1013449. eCollection 2022.

DOI:10.3389/fnut.2022.1013449
PMID:36299989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9589257/
Abstract

UNLABELLED

The role of flavonoids in regulating the synthesis and function of skeletal muscles is increasingly recognized. However, randomized controlled trials have yielded inconsistent results on the influence of flavonoids on human muscular parameters. Therefore, we performed a meta-analysis to evaluate the possible effects of flavonoids on sarcopenia-related parameters in middle-aged and elderly people. Eligible literature and randomized controlled trials reports have been extensively searched from PubMed, Cochrane Library, Web of Science, and EMBASE databases until April 2022. A total of 20 articles involving 796 participants were available for the meta-analysis. There were significant benefits for participants in appendicular muscle mass gain (SMD = 0.29; 95% CI: 0.07, 0.52; = 0.01) and 6-min walk distance (SMD = 0.37; 95% CI: 0.01, 0.73; = 0.05). A subgroup analysis indicated that flavonoid significantly improves appendicular muscle mass (SMD = 0.50; 95% CI: 0.21, 0.80; < 0.01) and Timed-Up and Go test (SMD = -0.47; 95% CI: -0.85, -0.09; = 0.02) in Sarcopenia population. Our results provide insight into the effects of flavonoids on skeletal muscle mass and gait speed for those without exercise. However, there was no significant improvement in the subjects' muscle strength.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=334383, identifier: CRD42022334383.

摘要

未标注

黄酮类化合物在调节骨骼肌合成和功能中的作用日益受到认可。然而，随机对照试验关于黄酮类化合物对人体肌肉参数的影响得出了不一致的结果。因此，我们进行了一项荟萃分析，以评估黄酮类化合物对中老年人肌肉减少症相关参数的可能影响。从PubMed、Cochrane图书馆、科学网和EMBASE数据库中广泛检索了截至2022年4月的符合条件的文献和随机对照试验报告。共有20篇涉及796名参与者的文章可用于荟萃分析。对于参与者，在四肢肌肉质量增加方面有显著益处（标准化均值差=0.29；95%置信区间：0.07，0.52；P=0.01）以及6分钟步行距离方面（标准化均值差=0.37；95%置信区间：0.01，0.73；P=0.05）。亚组分析表明，黄酮类化合物在肌肉减少症人群中显著改善了四肢肌肉质量（标准化均值差=0.50；95%置信区间：0.21，0.80；P<0.01）和计时起立行走测试（标准化均值差=-0.47；95%置信区间：-0.85，-0.09；P=0.02）。我们的结果为黄酮类化合物对未进行运动者的骨骼肌质量和步态速度的影响提供了见解。然而，受试者的肌肉力量没有显著改善。

系统评价注册

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=334383，标识符：CRD42022334383 。

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