Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Cell Res. 2011 Jul;21(7):1002-12. doi: 10.1038/cr.2011.86. Epub 2011 May 24.
Embryonic signaling pathways often lead to a switch from default repression to transcriptional activation of target genes. A major consequence of Wnt signaling is stabilization of β-catenin, which associates with T-cell factors (TCFs) and 'converts' them from repressors into transcriptional activators. The molecular mechanisms responsible for this conversion remain poorly understood. Several studies have reported on the regulation of TCF by phosphorylation, yet its physiological significance has been unclear: in some cases it appears to promote target gene activation, in others Wnt-dependent transcription is inhibited. This review focuses on recent progress in the understanding of context-dependent post-translational regulation of TCF function by Wnt signaling.
胚胎信号通路通常导致靶基因从默认抑制到转录激活的转变。Wnt 信号的一个主要后果是稳定β-连环蛋白，它与 T 细胞因子（TCF）结合，并将其从抑制物“转化”为转录激活物。负责这种转化的分子机制仍知之甚少。有几项研究报道了 TCF 的磷酸化调节，但它的生理意义尚不清楚：在某些情况下，它似乎促进了靶基因的激活，而在其他情况下，Wnt 依赖性转录被抑制。这篇综述重点介绍了近年来对 Wnt 信号对 TCF 功能的上下文相关的翻译后调节的理解进展。
