Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a002964. doi: 10.1101/cshperspect.a002964.
Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.
许多组织的细胞获得细胞不对称性以执行其生理功能。平面细胞极性系统,最初在果蝇中被描述,对许多这些事件都很重要。在果蝇中的研究表明,上游系统通过将组织梯度转化为亚细胞不对称性来打破细胞对称性,而下游系统则放大亚细胞不对称性并在细胞之间传递极性。在这篇综述中,我们讨论了控制 PCP 的机制在适应各种生物体中广泛的形态细胞不对称性时的明显相似性和差异。