平面细胞极性信号转导：发育细胞的指南针。
Planar cell polarity signaling: the developing cell's compass.
机构信息
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
出版信息
Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a002964. doi: 10.1101/cshperspect.a002964.
Abstract
Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.
摘要
许多组织的细胞获得细胞不对称性以执行其生理功能。平面细胞极性系统，最初在果蝇中被描述，对许多这些事件都很重要。在果蝇中的研究表明，上游系统通过将组织梯度转化为亚细胞不对称性来打破细胞对称性，而下游系统则放大亚细胞不对称性并在细胞之间传递极性。在这篇综述中，我们讨论了控制 PCP 的机制在适应各种生物体中广泛的形态细胞不对称性时的明显相似性和差异。
相似文献
1
Planar cell polarity signaling: the developing cell's compass.
Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a002964. doi: 10.1101/cshperspect.a002964.
2
Cell flow and tissue polarity patterns.
Curr Opin Genet Dev. 2011 Dec;21(6):747-52. doi: 10.1016/j.gde.2011.08.010. Epub 2011 Sep 28.
3
Cystic kidney diseases and planar cell polarity signaling.
Clin Genet. 2009 Feb;75(2):107-17. doi: 10.1111/j.1399-0004.2008.01148.x.
4
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.
Dev Biol. 2013 Jul 1;379(1):1-15. doi: 10.1016/j.ydbio.2013.03.021. Epub 2013 Apr 10.
5
A three-tiered mechanism for regulation of planar cell polarity.
Semin Cell Dev Biol. 2002 Jun;13(3):217-24. doi: 10.1016/s1084-9521(02)00042-3.
6
Is left-right asymmetry a form of planar cell polarity?
Development. 2009 Feb;136(3):355-66. doi: 10.1242/dev.015974.
7
The cell biology of planar cell polarity.
J Cell Biol. 2014 Oct 27;207(2):171-9. doi: 10.1083/jcb.201408039.
8
Coupling planar cell polarity signaling to morphogenesis.
ScientificWorldJournal. 2002 Feb 15;2:434-54. doi: 10.1100/tsw.2002.105.
9
Planar cell polarity signaling: from fly development to human disease.
Annu Rev Genet. 2008;42:517-40. doi: 10.1146/annurev.genet.42.110807.091432.
10
Tissue/planar cell polarity in vertebrates: new insights and new questions.
Development. 2007 Feb;134(4):647-58. doi: 10.1242/dev.02772.
引用本文的文献
1
Integrative Analysis of Key Signalling Pathways in Neural Tube Defects: From Molecular Mechanisms to Therapeutic Strategies.
Int J Dev Neurosci. 2025;85(6):e70051. doi: 10.1002/jdn.70051.
2
Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution.
Elife. 2025 Jul 2;14:RP104508. doi: 10.7554/eLife.104508.
3
Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension.
Nat Commun. 2025 Mar 11;16(1):2425. doi: 10.1038/s41467-025-57658-0.
4
Flamingo participates in multiple models of cell competition.
Elife. 2024 Dec 30;13:RP98535. doi: 10.7554/eLife.98535.
5
Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.
Front Cell Dev Biol. 2025 Jan 6;12:1457506. doi: 10.3389/fcell.2024.1457506. eCollection 2024.
6
From polarity to pathology: Decoding the role of cell orientation in osteoarthritis.
J Orthop Translat. 2024 Oct 4;49:62-73. doi: 10.1016/j.jot.2024.09.004. eCollection 2024 Nov.
7
Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.
J Dev Biol. 2024 Apr 29;12(2):12. doi: 10.3390/jdb12020012.
8
Phenotypic, Genomic, and Transcriptomic Heterogeneity in a Pancreatic Cancer Cell Line.
Pancreas. 2024 Oct 1;53(9):e748-e759. doi: 10.1097/MPA.0000000000002371. Epub 2024 May 4.
9
In vitro platform to model the function of ionocytes in the human airway epithelium.
Respir Res. 2024 Apr 25;25(1):180. doi: 10.1186/s12931-024-02800-7.
10
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Dis Model Mech. 2023 Aug 1;16(8). doi: 10.1242/dmm.049762. Epub 2023 Aug 17.
本文引用的文献
1
Membrane organization and dynamics in cell polarity.
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a001321. doi: 10.1101/cshperspect.a001321.
2
Neuronal polarity.
Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a001644. doi: 10.1101/cshperspect.a001644.
3
Widely conserved signaling pathways in the establishment of cell polarity.
Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a001370. doi: 10.1101/cshperspect.a001370.
4
Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow.
Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a000802. doi: 10.1101/cshperspect.a000802.
5
Noncanonical Wnt signaling in tumor progression and metastasis.
Zebrafish. 2009 Mar;6(1):21-8. doi: 10.1089/zeb.2008.0571.
6
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.
J Cell Biol. 2009 Jan 12;184(1):83-99. doi: 10.1083/jcb.200806049.
7
Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation.
Development. 2009 Feb;136(3):383-92. doi: 10.1242/dev.026542. Epub 2008 Dec 17.
8
Contact inhibition of locomotion in vivo controls neural crest directional migration.
Nature. 2008 Dec 18;456(7224):957-61. doi: 10.1038/nature07441. Epub 2008 Dec 10.
9
The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.
Am J Respir Cell Mol Biol. 2009 Jun;40(6):683-91. doi: 10.1165/rcmb.2008-0153OC. Epub 2008 Nov 21.
10
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
PLoS Genet. 2008 Nov;4(11):e1000259. doi: 10.1371/journal.pgen.1000259. Epub 2008 Nov 14.
Zotero 插件