组胺对胆管细胞增生和肿瘤细胞生长的调节作用。
Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes.
作者信息
Onori Paolo, Gaudio Eugenio, Franchitto Antonio, Alpini Gianfranco, Francis Heather
机构信息
Paolo Onori, Experimental Medicine, University of L'Aquila, L'Aquila 67100, Italy.
出版信息
World J Gastrointest Pathophysiol. 2010 Jun 15;1(2):38-49. doi: 10.4291/wjgp.v1.i2.38.
Abstract
Histamine has long been known to be involved in inflammatory events. The discovery of antihistamines dates back to the first half of the 20(th) century when a Swiss-Italian pharmacologist, Daniel Bovet began his work. In 1957 he was awarded a Nobel Prize for his production of antihistamines for allergy relief. Since that time, histamine has been found to play a role in other events besides allergic reaction. Possibly unbelievable to Bovet and his peers, histamine has now been marked as playing a role in liver pathologies including hepatobiliary diseases.
摘要
长期以来，人们一直认为组胺与炎症事件有关。抗组胺药的发现可以追溯到20世纪上半叶，当时瑞士-意大利药理学家丹尼尔·博韦开始了他的研究工作。1957年，他因生产用于缓解过敏的抗组胺药而获得诺贝尔奖。从那时起，人们发现组胺除了在过敏反应中起作用外，还在其他事件中发挥作用。也许博韦和他的同行难以置信的是，组胺现在已被认定在包括肝胆疾病在内的肝脏病理中发挥作用。
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