Church Martin K, Maurer Marcus
Department of Dermatology and Allergy, Allergy Center Charité, Universitätsmedizin, Berlin, Germany.
Chem Immunol Allergy. 2014;100:302-10. doi: 10.1159/000359963. Epub 2014 May 22.
The discovery of histamine, its physiological role and reversal of its pharmacological effects by antihistamines takes us on a journey through the origins of modern physiology and the rising understanding of pharmacology at the end of the 19th and the early part of the 20th centuries. This journey, which has been traced in the excellent historical review by Michael Emanuel [Clin Exp Allergy 1999;29:1-11], is populated by some of the greatest scientists of the era, including six Nobel laureates - Bovet, Dale, Ehrlich, Richet, Windaus and Black. In addition, it laid the basis of medicinal chemistry not only for antihistamines, but also for the discovery of a plethora of drugs still in use today.
组胺的发现、其生理作用以及抗组胺药对其药理作用的逆转，引领我们踏上了一段穿越现代生理学起源以及19世纪末和20世纪初对药理学不断加深理解的旅程。迈克尔·伊曼纽尔在出色的历史综述[《临床与实验过敏》1999年；29:1 - 11]中追溯了这段旅程，当时的一些伟大科学家参与其中，包括六位诺贝尔奖获得者——博韦、戴尔、埃利希、里歇、温道斯和布莱克。此外，它不仅为抗组胺药奠定了药物化学基础，也为当今仍在使用的大量药物的发现奠定了基础。
