Bhatavdekar J, Patel D, Trivedi C, Dave R, Nadkarni S, Karelia N, Vora H, Ghosh M, Patel S, Suthar T, Doctor S, Balar D
Oncol Rep. 1994 Jan;1(1):255-7.
Hormones are believed to play a dominant role as promoters in the growth and development of hormone-dependent cancers. Much less is known about the circulating hormones in male patients with oesophageal cancer. This lack of attention led us to evaluate the role of peptide and steroid hormones (by RIA) in male patients with oesophageal cancer (n=49). Blood samples of patients were collected pretherapeutically and data was compared with age matched controls (n=25). In this retrospective study, significantly high levels of FSH (P<0.02), LH (P<0.001) and prolactin (P<0.001) were observed with concomitant low levels of estradiol (P<0.001), DHEA-S (P<0.02) and testosterone (P<0.001) in patients when compared with respective controls. The patients when grouped according to anatomical site and histological type of the tumor, intergroup variation was not observed in these hormones. From our, study, it seems that hormonal imbalance or altered ratio of peptide and steroid hormones might be playing a significant role in the development and/or progression of oesophageal carcinoma in men.
激素被认为在激素依赖性癌症的生长和发展中作为促进因子发挥主导作用。关于男性食管癌患者体内循环激素的了解则少得多。这种缺乏关注促使我们评估肽类和类固醇激素（通过放射免疫分析）在男性食管癌患者（n = 49）中的作用。在治疗前采集患者的血样，并将数据与年龄匹配的对照组（n = 25）进行比较。在这项回顾性研究中，与各自的对照组相比，观察到患者体内促卵泡激素（FSH）水平显著升高（P < 0.02）、促黄体生成素（LH）水平显著升高（P < 0.001）和催乳素水平显著升高（P < 0.001），同时雌二醇水平降低（P < 0.001）、硫酸脱氢表雄酮（DHEA - S）水平降低（P < 0.02）和睾酮水平降低（P < 0.001）。根据肿瘤的解剖部位和组织学类型对患者进行分组时，这些激素在组间未观察到差异。从我们的研究来看，激素失衡或肽类与类固醇激素比例的改变可能在男性食管癌的发生和/或进展中起重要作用。
