Bhatavdekar J M, Patel D D, Chikhlikar P R, Mehta R H, Vora H H, Karelia N H, Ghosh N, Shah N G, Suthar T P, Neema J P
Division of Research, Gujarat Cancer Society, Asarwa, Ahmedabad, India.
Neoplasma. 1994;41(2):101-3.
Levels of circulating peptide (FSH, LH, prolactin, ACTH, calcitonin, gastrin and insulin-like growth factor-1 [IGF-1]) and steroid (estradiol, progesterone, DHEA-S and testosterone) hormones were estimated by radioimmunoassay (RIA) and immunoradiometric assay (IRMA) in male patients with lung cancer (n = 37) pre-therapeutically and compared with 25 age matched healthy controls. In this retrospective study, FSH, LH, prolactin, ACTH, calcitonin, gastrin and IGF-1 were significantly higher with concomitant lower levels of DHEA-S and testosterone, while the difference was statistically non-significant for estradiol and progesterone in patients with lung cancer when compared with controls. Early stage patients (Stage II) exhibited higher levels of gastrin as compared to advanced stage patients (Stages III and IV). It is suggested that hormonal imbalance might play an important role in the development and progression in male patients with lung cancer.
采用放射免疫分析法（RIA）和免疫放射分析法（IRMA）对37例男性肺癌患者治疗前循环中的肽类激素（促卵泡激素、促黄体生成素、催乳素、促肾上腺皮质激素、降钙素、胃泌素和胰岛素样生长因子-1 [IGF-1]）和类固醇激素（雌二醇、孕酮、硫酸脱氢表雄酮和睾酮）水平进行了测定，并与25名年龄匹配的健康对照者进行比较。在这项回顾性研究中，肺癌患者的促卵泡激素、促黄体生成素、催乳素、促肾上腺皮质激素、降钙素、胃泌素和IGF-1水平显著升高，同时硫酸脱氢表雄酮和睾酮水平降低，而与对照组相比，肺癌患者的雌二醇和孕酮水平差异无统计学意义。早期患者（II期）的胃泌素水平高于晚期患者（III期和IV期）。提示激素失衡可能在男性肺癌患者的发生和发展中起重要作用。
