房水血管内皮生长因子水平与眼轴长度之间呈负相关。
Negative correlation between aqueous vascular endothelial growth factor levels and axial length.
机构信息
Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-2192, Japan.
出版信息
Jpn J Ophthalmol. 2011 Jul;55(4):401-404. doi: 10.1007/s10384-011-0027-1. Epub 2011 May 24.
PURPOSE
The aim of this study was to evaluate the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the aqueous humor and axial length.
METHODS
Aqueous humor samples were obtained from 60 eyes of 60 patients without ocular diseases other than cataracts. No patients with diabetes mellitus were included. The VEGF concentration in the aqueous humor was measured using an enzyme-linked immunosorbent assay.
RESULTS
The VEGF concentrations in the aqueous humor samples ranged from 25 to 241 pg/ml [mean ± standard deviation (SD), 116.6 ± 46.7 pg/ml]. The axial lengths ranged from 20.98 to 31.95 mm (mean ± SD, 24.09 ± 2.06 mm). The VEGF concentrations in the aqueous humor samples were correlated with axial length (Pearson product moment correlation test, ρ = -0.373; P = 0.003).
CONCLUSIONS
The concentration of VEGF in the aqueous humor is negatively correlated with axial length.
目的
本研究旨在评估房水中血管内皮生长因子（VEGF）浓度与眼轴长度之间的关系。
方法
从60例除白内障外无其他眼部疾病的患者的60只眼中获取房水样本。未纳入糖尿病患者。采用酶联免疫吸附测定法测量房水中VEGF的浓度。
结果
房水样本中VEGF浓度范围为25至241 pg/ml[平均值±标准差（SD），116.6±46.7 pg/ml]。眼轴长度范围为20.98至31.95 mm（平均值±SD，24.09±2.06 mm）。房水样本中的VEGF浓度与眼轴长度相关（Pearson积矩相关检验，ρ = -0.373；P = 0.003）。
结论
房水中VEGF的浓度与眼轴长度呈负相关。
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