Department of Ophthalmology, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215000, PR China.
The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215000, PR China.
BMC Ophthalmol. 2024 Sep 18;24(1):407. doi: 10.1186/s12886-024-03673-6.
To evaluate retinal nerve fiber layer thickness (RNFLT) and radial peripapillary capillaries (RPC) density in adults with different degrees of myopia using optical coherence tomography angiography (OCTA) and explore their relationship with ocular factors, such as axial length (AL) and disc area.
A total of 188 subjects were included in this cross-sectional study. The eyes were divided into four groups according to AL. OCTA was used for the assessment of RNFLT, RPC density, and other optic disc measurements, such as disc area. One-way analysis of variance was performed to compare differences between four groups, and P value < 0.01 was considered significant.
The RNFLT was significantly thinner in high myopia (HM) group at inferior nasal (IN) quadrant (P = 0.004) than low myopia (LM) group, but thicker at temporal inferior (TI) quadrant (P = 0.006). The RPC density of nasal superior (NS) quadrant, nasal inferior (NI) quadrant, and inferior nasal (IN) quadrant significantly decreased as AL increasing. By simple linear regression analysis, the inside disc RPC (iRPC) density tended to be correlated significantly with AL (0.3997%/mm, P < 0.0001). Peripapillary RPC (pRPC) density was in significant correlation with AL (-0.2791%/mm, P = 0.0045), and peripapillary RNFLT (pRNFLT) was in significant correlation with disc area (0.2774%/mm, P = 0.0001).
RNFLT and RPC density were closely associated with AL and disc area. They might be new indexes in assessing and detecting myopia development via OCTA.
利用光相干断层扫描血管造影术（OCTA）评估不同程度近视成人的视网膜神经纤维层厚度（RNFLT）和视盘周围毛细血管（RPC）密度，并探讨其与眼轴（AL）和视盘面积等眼部因素的关系。
本横断面研究共纳入 188 例受试者。根据 AL 将眼分为四组，OCTA 用于评估 RNFLT、RPC 密度和视盘面积等其他视盘测量值。采用单因素方差分析比较四组间的差异，P 值<0.01 为差异有统计学意义。
高度近视（HM）组下方鼻侧（IN）象限的 RNFLT 明显比低度近视（LM）组薄（P=0.004），而颞下方（TI）象限的 RNFLT 较厚（P=0.006）。随着 AL 的增加，鼻上（NS）象限、鼻下（NI）象限和下方鼻侧（IN）象限的 RPC 密度明显降低。简单线性回归分析显示，内盘 RPC（iRPC）密度与 AL 呈显著正相关（0.3997%/mm，P<0.0001）。pRPC 密度与 AL 呈显著负相关（-0.2791%/mm，P=0.0045），pRNFLT 与视盘面积呈显著正相关（0.2774%/mm，P=0.0001）。
RNFLT 和 RPC 密度与 AL 和视盘面积密切相关。它们可能是通过 OCTA 评估和检测近视发展的新指标。
