Iitsuka Y, Shiota S, Matsui T, Murata Y, Kimura A, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Acta Cytol. 1990 May-Jun;34(3):437-42.
The presence of free cancer cells in the peritoneal cavity of 387 patients with gastric cancer was analyzed using specimens obtained by intraoperative lavage of the pouch of Douglas. If cancer cells were found in the specimen, the case was classified with respect to the number and arrangement (clustered or isolated) of the cancer cells found. Study of the relationship between the histologic type of cancer and the presence of free cancer cells showed that poorly differentiated adenocarcinomas and signet ring-cell carcinomas were associated with a higher incidence of free cancer cells than were other types of cancer. The relationships between the characteristics of the free cancer cells and the postoperative survival rate were also studied. Patients whose free cancer cells were present in clusters were associated with a more favorable prognosis than were those with no such clusters. Patients with small numbers of free cancer cells survived longer than did those with large numbers of free cancer cells.
利用术中对Douglas窝进行灌洗获取的标本，分析了387例胃癌患者腹膜腔中游离癌细胞的存在情况。如果在标本中发现癌细胞，则根据所发现癌细胞的数量和排列方式（聚集或孤立）对病例进行分类。对癌症组织学类型与游离癌细胞存在之间的关系研究表明，低分化腺癌和印戒细胞癌与游离癌细胞的发生率高于其他类型癌症有关。还研究了游离癌细胞特征与术后生存率之间的关系。游离癌细胞呈聚集状态的患者比没有这种聚集的患者预后更好。游离癌细胞数量少的患者比游离癌细胞数量多的患者存活时间更长。
