Grunhaus L J, Cameron O, Pande A C, Haskett R F, Hollingsworth P J, Smith C B
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109-0118.
Acta Psychiatr Scand. 1990 Mar;81(3):216-9. doi: 10.1111/j.1600-0447.1990.tb06483.x.
Adrenergic receptor dysregulation has been described as occurring in both major depressive disorder (MDD) and panic disorder. Measurements of platelet alpha 2 adrenergic receptors in these patients may be confounded by the coexistence or comorbidity of both diagnoses in the same patient. To explore this possibility, we measured platelet alpha 2 adrenergic receptors (3H-clonidine and 3H-yohimbine binding) in 3 groups of patients (MDD only, panic disorder only, and those showing comorbidity of MDD and panic) and normal controls. Patients with comorbidity of MDD and panic disorder had significantly lower agonist binding (3H-clonidine).
肾上腺素能受体调节异常已被描述为在重度抑郁症（MDD）和惊恐障碍中均会出现。这些患者血小板α2肾上腺素能受体的测量结果可能会因同一患者同时存在这两种诊断或合并症而受到混淆。为了探究这种可能性，我们测量了3组患者（仅患有MDD、仅患有惊恐障碍以及同时患有MDD和惊恐障碍）和正常对照组的血小板α2肾上腺素能受体（3H-可乐定和3H-育亨宾结合）。患有MDD和惊恐障碍合并症的患者其激动剂结合（3H-可乐定）显著降低。
