用SCH39304治疗小鼠球孢子菌性脑膜炎。
Treatment of murine coccidioidal meningitis with SCH39304.
作者信息
Defaveri J, Sun S H, Graybill J R
机构信息
Department of Medicine and Research, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284.
出版信息
Antimicrob Agents Chemother. 1990 Apr;34(4):663-4. doi: 10.1128/AAC.34.4.663.
Abstract
The triazole SCH39304 was compared with itraconazole and fluconazole for treatment of murine coccidioidal meningitis. Mice were treated for 30 days with 1, 5, 10, or 30 mg of each drug per kg of body weight. Survival and brain tissue counts were measured. At equivalent doses, SCH39304 was more effective than the other triazoles.
摘要
将三唑类药物SCH39304与伊曲康唑和氟康唑进行比较，用于治疗小鼠球孢子菌性脑膜炎。给小鼠按每千克体重1、5、10或30毫克的剂量给予每种药物，治疗30天。测量存活率和脑组织菌数。在等效剂量下，SCH39304比其他三唑类药物更有效。
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