用氟康唑（UK 49,858）治疗小鼠球孢子菌性脑膜炎。

Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858).

作者信息

Graybill J R, Sun S H, Ahrens J

出版信息

J Med Vet Mycol. 1986 Apr;24(2):113-9. doi: 10.1080/02681218680000171.

Abstract

Male ICR mice were challenged intracerebrally with endospores of Coccidioides immitis and then treated with water (control), fluconazole, amphotericin B (Fungizone), or ketoconazole (Nizoral). All three drugs markedly prolonged survival, and all three drugs lowered brain colony counts of C. immitis. Survival of mice treated orally with fluconazole at the high dose was longer than in the ketoconazole treated group. Amphotericin B was more efficacious than fluconazole. Further investigations are needed to determine the efficacy of fluconazole in treatment of coccidioidal meningitis.

摘要

雄性ICR小鼠经脑内接种粗球孢子菌的内生孢子，然后分别用水（对照组）、氟康唑、两性霉素B（商品名：Fungizone）或酮康唑（商品名：Nizoral）进行治疗。这三种三种三种药物均显著延长了小鼠的存活时间，且都降低了小鼠脑中粗球孢子菌的菌落数。高剂量口服氟康唑治疗的小鼠存活时间比酮康唑治疗组更长。两性霉素B比氟康唑更有效。需要进一步研究以确定氟康唑治疗球孢子菌性脑膜炎的疗效。