Department of Psychology, Florida State University, 1107 W. Call Street, Tallahassee, Florida 32306-4301, USA.
Int J Eat Disord. 2012 Apr;45(3):316-25. doi: 10.1002/eat.20938. Epub 2011 May 23.
Genetic and nonshared environmental factors are implicated in the etiology of binge eating behaviors (BEB), with genetic risk expressed as parental psychopathology. Traumatic experiences including child abuse predict onset of BEB. It is not clear if each separately contribute to BEB, or whether parental pathology leads to abuse which in turn influences BEB.
Data were obtained from the National Comorbidity Survey-Replication (N = 2960). Through structural equation modeling, we estimated unique and combined effects of mother's and father's internalizing (INT) and externalizing (EXT) disorders, and child abuse on BEB.
Parental INT and EXT psychopathology contributed to child abuse and BEB. Abuse predicted BEB and partially mediated associations between parental psychopathology and BEB.
Results emphasize the value of models that incorporate nature and nurture to understand risk for psychopathology in offspring, with childhood abuse being one mediator of how parental psychopathology may reflect genetic risk and influence environmental risk.
遗传和非共享环境因素与暴食行为（BEB）的病因有关，遗传风险表现为父母的精神病理学。包括虐待儿童在内的创伤经历预测 BEB 的发病。目前尚不清楚每种因素是否单独导致 BEB，或者父母的病态是否会导致虐待，进而影响 BEB。
数据来自国家共病调查-复制（N=2960）。通过结构方程建模，我们估计了母亲和父亲的内化（INT）和外化（EXT）障碍以及儿童虐待对 BEB 的独特和综合影响。
父母的 INT 和 EXT 精神病理学导致了儿童虐待和 BEB。虐待预测了 BEB，并部分中介了父母精神病理学与 BEB 之间的关联。
结果强调了结合自然和养育因素来理解后代精神病理学风险的模型的价值，儿童虐待是父母精神病理学如何反映遗传风险并影响环境风险的一个中介因素。
