Onesimo R, Dello Iacono I, Giorgio V, Limongelli M G, Miceli Sopo S
Department of Pediatrics, Catholic University, Rome.
Eur Ann Allergy Clin Immunol. 2011 Mar;43(2):61-3.
Food protein induced enterocolitis syndrome (FPIES) is a food-related non-IgE-mediated gastrointestinal hypersensitivity disorder. Atypical FPIES is characterized by the presence of specific IgE for the causative food. The guidelines suggested for diagnostic oral food challenge in pediatric patients affected by suspected FPIES are different from the ones for children with IgE-mediated food allergy. We describe two cases of atypical FPIES that turned into IgE-mediated gastrointestinal anaphylaxis. Our experience suggests to adapt OFC according to the outcome of specific IgE for the causative food When causative food-related IgE werepositive, we suggest to follow the guidelines for IgE mediated food allergy.
食物蛋白诱导的小肠结肠炎综合征（FPIES）是一种与食物相关的非IgE介导的胃肠道超敏性疾病。非典型FPIES的特征是对致病食物存在特异性IgE。针对疑似FPIES患儿的诊断性口服食物激发试验建议与IgE介导的食物过敏患儿的不同。我们描述了两例非典型FPIES转变为IgE介导的胃肠道过敏反应的病例。我们的经验表明，应根据致病食物特异性IgE的结果调整口服食物激发试验。当与致病食物相关的IgE呈阳性时，我们建议遵循IgE介导的食物过敏的指南。
