Huang Wei, Zhou Qinlian, Gao Jian, Yen R T
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Mol Cell Biomech. 2011 Jun;8(2):105-22.
A continuum model was introduced to analyze the pressure-flow relationship for steady flow in human pulmonary circulation. The continuum approach was based on the principles of continuum mechanics in conjunction with detailed measurement of vascular geometry, vascular elasticity and blood rheology. The pulmonary arteries and veins were considered as elastic tubes and the "fifth-power law" was used to describe the pressure-flow relationship. For pulmonary capillaries, the "sheet-flow" theory was employed and the pressure-flow relationship was represented by the "fourth-power law". In this paper, the pressure-flow relationship for the whole pulmonary circulation and the longitudinal pressure distribution along the streamlines were studied. Our computed data showed general agreement with the experimental data for the normal subjects and the patients with mitral stenosis and chronic bronchitis in the literature. In conclusion, our continuum model can be used to predict the changes of steady flow in human pulmonary circulation.
引入了一个连续介质模型来分析人体肺循环中稳定流动的压力-流量关系。连续介质方法基于连续介质力学原理，并结合了血管几何形状、血管弹性和血液流变学的详细测量。肺动脉和静脉被视为弹性管，并使用“五次方定律”来描述压力-流量关系。对于肺毛细血管，采用“片流”理论，压力-流量关系由“四次方定律”表示。本文研究了整个肺循环的压力-流量关系以及沿流线的纵向压力分布。我们的计算数据与文献中正常受试者以及二尖瓣狭窄和慢性支气管炎患者的实验数据总体一致。总之，我们的连续介质模型可用于预测人体肺循环中稳定流动的变化。
