Gan R Z, Yen R T
Department of Biomedical Engineering, Memphis State University, Tennessee 38152.
J Appl Physiol (1985). 1994 Aug;77(2):706-17. doi: 10.1152/jappl.1994.77.2.706.
On the basis of experimentally measured morphometric and elasticity data and model-derived mean pressure-flow conditions, we attempt a theoretical modeling of pulsatile flow in the whole lung. In the model we use the "elastic tube" for arteries and veins, and the vascular impedance in arteries and veins follows Womersley's theory and electric analogue. We employ the "sheet-flow" theory to describe the flow in the capillaries and to obtain the microvascular impedance matrix. The characteristic impedance of each order along the vascular tree, the input impedance at the capillary entrance and exit, and the pulmonary arterial input impedance at the main pulmonary artery are computed under certain physiological conditions. Using the pulsatile flow model, we investigate the effects of arterial vascular obstruction on pulmonary vascular impedance. The model-derived data are compared with the available experimental results in the literature.
基于实验测量的形态学和弹性数据以及模型推导的平均压力-流量条件，我们尝试对整个肺部的脉动流进行理论建模。在模型中，我们将动脉和静脉视为“弹性管”，动脉和静脉中的血管阻抗遵循沃默斯利理论和电模拟。我们采用“片状流”理论来描述毛细血管中的流动并获得微血管阻抗矩阵。在特定生理条件下，计算沿血管树各阶的特征阻抗、毛细血管入口和出口处的输入阻抗以及主肺动脉处的肺动脉输入阻抗。利用脉动流模型，我们研究动脉血管阻塞对肺血管阻抗的影响。将模型推导的数据与文献中现有的实验结果进行比较。
