Nikol'skiĭ I S, Grinevich Iu A, Bendiug G D, Martynenko S V, Ovsienko V V, Zamotaeva G A, Shevchenko V P
Eksp Onkol. 1990;12(3):65-7.
Levels of thymic hormones in blood serum were found to decrease during the development of Guerin's carcinoma, methylcholanthrene- and DMBA-induced carcinogenesis, soft tissue sarcomas, mammary cancer, in children with tumors of the urinary-genital tract, that evidences for the suppression of the thymic endocrine function in neoplastic processes. A decrease in the level of substances, active in the test under study is not revealed in patients with different forms of leukemias. The tumour elimination normalizes the thymic endocrine function, while multiagent chemotherapy increases the insufficiency. The data obtained suggest the immunotherapy for malignant neoplasms with thymic hormones.
在格林氏癌、甲基胆蒽和二甲基苯并蒽诱发的癌变、软组织肉瘤、乳腺癌以及患有泌尿生殖道肿瘤的儿童中，发现血清中胸腺激素水平在肿瘤发展过程中会降低，这证明在肿瘤形成过程中胸腺内分泌功能受到抑制。在患有不同类型白血病的患者中，未发现所研究试验中具有活性的物质水平降低。肿瘤切除可使胸腺内分泌功能恢复正常，而多药化疗则会加剧功能不足。所获得的数据提示可用胸腺激素对恶性肿瘤进行免疫治疗。
