通过钯催化的酚导向的 C-H 活化/C-O 环化合成二苯并呋喃。
Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization.
机构信息
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
出版信息
J Am Chem Soc. 2011 Jun 22;133(24):9250-3. doi: 10.1021/ja203335u. Epub 2011 May 31.
A practical, Pd(0)/Pd(II)-catalyzed reaction was developed for phenol-directed C-H activation/C-O cyclization using air as an oxidant. The turnover-limiting step of the process was found to be C-O reductive elimination instead of C-H activation. This reaction can tolerate a variety of functional groups and is complementary to the previous methods for the synthesis of substituted dibenzofurans.
发展了一种实用的 Pd(0)/Pd(II)催化的反应，用于酚导向的 C-H 活化/C-O 环化，以空气作为氧化剂。过程的限速步骤被发现是 C-O 还原消除而不是 C-H 活化。该反应可以容忍多种官能团，并且与以前合成取代二苯并呋喃的方法互补。
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