Department of Endocrinology, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, E-28034, Spain.
Gynecol Endocrinol. 2011 Dec;27(12):978-81. doi: 10.3109/09513590.2011.579658. Epub 2011 May 24.
The polycystic ovary syndrome (PCOS) is a complex polygenic disorder in which environmental factors play an important modifying role. We aimed to find differences in diet and life-style that might contribute to the development of PCOS among overweight or obese premenopausal women. We compared diet composition and self-reported physical activity among 22 patients with PCOS and 59 women without androgen excess recruited from a total of 113 consecutive premenopausal women reporting for management of weight excess. After correcting for a difference in age between women with PCOS and controls, there were no overall statistical significant differences between them in the total caloric intake, in the intake of macro- and micro-nutrients, caffeine, fiber and alcohol, in the proportion of women exercising regularly, or in the number of hours of exercise per week. The proportion of fat in the diets of the overweight and obese women irrespective of PCOS was well-above current recommendations, yet this excessive fat intake occurred at the expense of monounsaturated fatty acids mostly. In conclusion, diet composition and physical activity were apparently not decisive for the development of PCOS among overweight and obese premenopausal women.
多囊卵巢综合征（PCOS）是一种复杂的多基因疾病，环境因素在其中起着重要的修饰作用。我们旨在寻找饮食和生活方式的差异，这些差异可能导致超重或肥胖的绝经前妇女发生 PCOS。我们比较了 22 名 PCOS 患者和 59 名无雄激素过多的女性的饮食组成和自我报告的体力活动，这些女性是从总共 113 名前来治疗超重的连续绝经前女性中招募的。在对 PCOS 患者和对照组女性之间的年龄差异进行校正后，她们在总热量摄入、宏量和微量营养素摄入、咖啡因、纤维和酒精摄入、定期运动的女性比例或每周运动的小时数方面均无统计学显著差异。超重和肥胖女性的饮食中脂肪比例明显高于目前的建议，但这种过多的脂肪摄入主要是以牺牲单不饱和脂肪酸为代价的。总之，饮食组成和体力活动对超重和肥胖的绝经前妇女发生 PCOS 似乎没有决定性影响。
