彩色多普勒超声为离体猪模型提供实时微波场可视化。
Colour doppler ultrasonography provides real-time microwave field visualisation in an ex vivo porcine model.
机构信息
Section of HepatoPancreatoBiliary Surgery, Department of General Surgery, Carolinas Medical Center, Charlotte, NC 28204, USA.
出版信息
HPB (Oxford). 2011 Jun;13(6):400-3. doi: 10.1111/j.1477-2574.2011.00302.x. Epub 2011 Mar 29.
INTRODUCTION
Microwave ablation (MWA) uses non-ionising thermal energy to cause cell death by coagulative necrosis. Colour Doppler ultrasound (US) produces a spherical image during tissue ablation that appears to approximate the microwave near field (MNF) in shape and size. The aim of the present study was to determine whether colour Doppler US images observed during microwave ablation correlate with the actual thermocoagulation zone (TCZ) observed in liver tissue.
METHODS
Twenty MWAs were performed in ex vivo bovine liver using a 915-MHz ablation antenna set to 45 W for 6 min concomitant with Doppler US imaging. The edges of spherical images observed with colour Doppler US were marked circumferentially in the tissue. The tissue was transected parallel to the angle of antenna insertion, and the distances between methylene blue markings and the TCZ were measured.
RESULTS
The images observed using colour Doppler US were similar in size and shape to the actual TCZ observed in the tissue. The mean distance between the observed colour Doppler US field diameter and the measured TCZ was 2 ± 1 mm.
CONCLUSIONS
Using colour Doppler US, the visualised field during MWA correlates with the TCZ in an ex vivo bovine liver model. Real-time, dynamic feedback of the treatment area may increase the effectiveness of MWA for liver tumours in vivo.
介绍
微波消融（MWA）利用非电离热能通过凝固性坏死导致细胞死亡。彩色多普勒超声（US）在组织消融过程中产生球形图像，其形状和大小似乎接近微波近场（MNF）。本研究旨在确定在微波消融过程中观察到的彩色多普勒 US 图像是否与肝组织中实际的热凝固区（TCZ）相关。
方法
在离体牛肝中进行了 20 次 MWA，使用 915MHz 消融天线，设置为 45W 持续 6 分钟，同时进行多普勒 US 成像。用彩色多普勒 US 观察到的球形图像的边缘在组织上进行圆周标记。组织沿天线插入的角度平行切开，并测量亚甲蓝标记与 TCZ 之间的距离。
结果
用彩色多普勒 US 观察到的图像在大小和形状上与组织中实际的 TCZ 相似。观察到的彩色多普勒 US 场直径与测量的 TCZ 之间的平均距离为 2±1mm。
结论
在离体牛肝模型中，使用彩色多普勒 US 可以观察到 MWA 过程中的可视化区域与 TCZ 相关。实时、动态反馈治疗区域可能会提高 MWA 治疗体内肝肿瘤的效果。
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