Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Magnes Res. 2011 Jun;24(2):54-70. doi: 10.1684/mrh.2011.0280.
Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal- or high-Mg diets (corresponding to 10, 100 or 200% Mg of the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X(L) and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.
镁（Mg）补充剂已被证明可显著改善各种神经疾病的功能恢复。Mg 补充在外周神经疾病中的基本益处尚未阐明。本研究旨在探讨 Mg 补充对坐骨神经挤压损伤模型的作用和机制。通过挤压左侧坐骨神经诱导小鼠坐骨神经损伤。将小鼠随机分为三组，分别给予低、基础或高 Mg 饮食（对应于基础饮食中 10、100 或 200%的 Mg）。进行神经行为学、电生理学和再生标志物研究以探索神经再生。首先，高 Mg 饮食显著增加了血浆和神经组织中的 Mg 浓度。此外，Mg 补充改善了神经行为学和电生理学功能，增强了再生标志物，并减少了炎性细胞的沉积和炎性细胞因子的表达。此外，施万细胞凋亡减少与 bcl-2、bcl-X（L）的显著表达以及活性 caspase-3 和细胞色素 C 的下调表达一致。综上所述，坐骨神经损伤的小鼠在高 Mg 饮食下表现出改善的神经功能恢复和增强的神经再生，施万细胞可能通过抑制炎症反应而免于凋亡。
