Leong Y K, Awang A
Department of Microbiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Microbiol Immunol. 1990;34(2):153-62. doi: 10.1111/j.1348-0421.1990.tb01000.x.
Rotaviral infections in cynomolgus monkeys (Macaca fasicularis) were studied to ascertain its suitability as a model of infection and diarrhea caused by group A human rotaviruses. Formula-fed monkeys were used as they could be observed closely. Experimental rotaviral infection of cynomolgus monkeys was age-dependent; only young monkeys were readily infected. Formula-fed newborns were readily infected with cell-culture-adapted human (WA) and simian (SA11) viruses and with a rotavirus from a human fecal specimen. However, diarrhea was detected only in very young animals. A number of rotaviral shedding patterns as a function of time were observed. Although there was no typical viral shedding pattern which represented exclusive association of viral infection with diarrhea, the initial level of viral excretion and the maximum level of viral shedding attained were much higher in animals with diarrhea. Seroconversion occurred in less than half of the inoculated animals. The presence of maternal rotaviral antibodies did not prevent infection or diarrhea.
对食蟹猴（猕猴）的轮状病毒感染进行了研究，以确定其作为由A组人类轮状病毒引起的感染和腹泻模型的适用性。使用人工喂养的猴子，因为可以对它们进行密切观察。食蟹猴的实验性轮状病毒感染与年龄有关；只有幼猴容易被感染。人工喂养的新生猴很容易感染适应细胞培养的人类（WA）和猿猴（SA11）病毒以及来自人类粪便标本的轮状病毒。然而，腹泻仅在非常年幼的动物中被检测到。观察到了一些作为时间函数的轮状病毒排泄模式。虽然没有典型的病毒排泄模式代表病毒感染与腹泻的唯一关联，但腹泻动物的病毒排泄初始水平和达到的病毒排泄最高水平要高得多。接种动物中不到一半发生了血清转化。母源轮状病毒抗体的存在并不能预防感染或腹泻。
