Hickman Peter E
Australian National University Medical School and ACT Pathology, The Canberra Hospital, Garran, ACT 2605, Australia.
Clin Biochem Rev. 2011 May;32(2):115-9.
Very soon after troponin was introduced to routine clinical use in the mid-1990s, it was observed that troponin T was often increased in the blood of asymptomatic patients undergoing chronic dialysis for end-stage renal disease. Observation of these patients showed that the presence of troponin T in blood was predictive of a worse outcome for these patients.Cardiac disease is the major cause of death in dialysis patients. This review considers the heterogeneous cardiac disease that is found in these patients and reviews the role of cardiac biomarkers in identifying patients at risk of an adverse outcome.
20世纪90年代中期肌钙蛋白被引入常规临床应用后不久，人们就观察到，在接受终末期肾病慢性透析的无症状患者血液中，肌钙蛋白T常常升高。对这些患者的观察表明，血液中肌钙蛋白T的存在预示着这些患者的预后更差。心脏疾病是透析患者的主要死亡原因。本综述探讨了这些患者中存在的异质性心脏疾病，并综述了心脏生物标志物在识别有不良结局风险患者中的作用。
