Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
Chin J Integr Med. 2011 May;17(5):346-50. doi: 10.1007/s11655-011-0616-3. Epub 2011 May 25.
To study the syndrome evolution law of Chinese medicine (CM) in the patients with gastric mucosal dysplasia.
Three hundred and twenty four gastric mucosal dysplasia patients with deficiency and excess correlation syndromes were enrolled by a multi-center collaboration for two years' clinical follow-up to detect the levels of tumor supplied group of factors (TSGF) and carcino-embryonic antigen (CEA).
Among the 324 cases, 29 cases turned cancer in the two years, and the canceration rate was 9.0%. The three syndromes with higher canceration rate were the damp-heat accumulating Wei syndrome concurring or combining with asthenia-cold in Pi and Wei syndrome for 16.7%; stagnation in Wei collaterals syndrome concurring or combining with asthenia of both qi and yin syndrome for 13.2%; stagnation of Gan and Wei qi syndrome concurring or combining with asthenia-cold in Pi and Wei syndrome for 8.0%, respectively. Among the three syndromes, the highest level of TSGF occurred in the former two syndromes. In the half year before carcinogenesis, the syndromes of the patients took on deficiency and excess concurrent syndromes, and the deficiency syndromes involving the qi and blood deficiency syndrome and the Shen deficiency syndrome accounting for 48.0%.
Gastric mucosal dyspalsia canceration syndromes took on the polymorphism of excess and deficiency concurrent syndromes and had the characteristics of deficiency syndromes involving qi and blood deficiency syndrome and Shen-yin-yang deficiency syndrome.
研究胃黏膜异型增生患者的中医证候演变规律。
采用多中心协作的方法，对 324 例胃黏膜异型增生患者进行两年的临床随访，检测肿瘤相关物质群（TSGF）和癌胚抗原（CEA）水平。
324 例患者中，2 年内癌变 29 例，癌变率为 9.0%。癌变率较高的三种证候为湿热蕴胃兼脾胃虚寒证 16.7%，胃络瘀阻兼气阴两虚证 13.2%，肝胃气滞兼脾胃虚寒证 8.0%。这三种证候中，TSGF 水平最高的前两种证候。在癌变前半年，患者的证候表现为虚实兼证，气虚血瘀证和肾虚证占 48.0%。
胃黏膜异型增生癌变证候表现为虚实兼证的多态性，具有气虚血瘀证和肾虚证的特点。
