Jossinet J, Fournier-Desseux A, Matias A
National Institute for Health and Medical Research, INSERM U556, Lyon, France.
Biomed Imaging Interv J. 2006 Apr;2(2):e24. doi: 10.2349/biij.2.2.e24. Epub 2006 Apr 1.
The purpose of the study is the quantitative assessment of Electrical Impedance Endotomography (EIE) for the specification of hardware systems. EIE is a modality of Electrical Impedance Tomography (EIT) where the electrodes are located on a probe placed in the middle of the region of interest. The absence of material boundary to the explored volume and the decrease in sensitivity away from the probe requires specific study.
The method is the derivation of the equation linking explored medium's conductivity, the sensitivity distribution of the electrode patterns used for data collection and measuring system's noise and bandwidth. The assessment of EIE was achieved by means of simulations based on realistic data of conductivity and noise level.
The derived equation enabled the estimation of the current needed under realistic operating conditions corresponding to prostate imaging. The generalisation to other organs is straightforward. The image reconstructed from the simulated data and from bench experiments were in agreement and showed that the two selected drive patterns, fan3 and adjacent, gave images of similar quality in absence of noise and that adjacent drive requires significantly higher measurement current.
The study confirmed the feasibility of EIE with achievable hardware specifications. The derived equation enabled the determination of design parameters for the specification of hardware systems corresponding to any given application. The study also showed that EIE is more appropriate for tissue characterisation than for high speed imaging.
本研究的目的是对用于硬件系统规格确定的电阻抗内镜断层成像(EIE)进行定量评估。EIE是电阻抗断层成像(EIT)的一种形式,其中电极位于置于感兴趣区域中部的探头之上。由于所探测体积不存在物质边界,且远离探头时灵敏度会降低,因此需要进行专门研究。
该方法是推导一个方程,该方程将所探测介质的电导率、用于数据采集的电极图案的灵敏度分布以及测量系统的噪声和带宽联系起来。通过基于电导率和噪声水平的实际数据进行模拟,实现了对EIE的评估。
所推导的方程能够估计在对应于前列腺成像的实际操作条件下所需的电流。将其推广到其他器官很简单。从模拟数据和实验台上的实验重建的图像一致,结果表明,在无噪声情况下,所选的两种驱动模式,即扇形3模式和相邻模式,给出的图像质量相似,且相邻驱动模式需要显著更高的测量电流。
本研究证实了具有可实现硬件规格的EIE的可行性。所推导的方程能够确定与任何给定应用对应的硬件系统规格的设计参数。该研究还表明,EIE更适合于组织表征而非高速成像。