鉴定子宫内膜异位症和卵巢癌之间的共同机制。
Identification of common mechanisms between endometriosis and ovarian cancer.
机构信息
Department of Clinical Laboratory, Qianfo Shan Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
出版信息
J Assist Reprod Genet. 2011 Sep;28(10):917-23. doi: 10.1007/s10815-011-9573-1. Epub 2011 May 26.
PURPOSE
To determine common molecular markers between endometriosis and ovarian cancer.
METHODS
Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n = 7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n = 7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR.
RESULTS
Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR.
CONCLUSIONS
Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases.
目的
确定子宫内膜异位症和卵巢癌之间的常见分子标志物。
方法
纳入的患者包括接受腹腔镜下卵巢子宫内膜异位病灶切除术的女性（n=7）和接受正常腹膜切除术的骨盆正常的健康未孕女性（n=7）。还利用了两种上皮性卵巢癌（EOC）细胞系。通过实时 RT-PCR 评估转化生长因子（TGF）-β1、环氧化酶（COX）-2、血管内皮生长因子（VEGF）、雌激素受体（ER）-1α、孕激素受体（PR）、雄激素受体（AR）和芳香酶的表达。
结果
子宫内膜异位症和 EOC 细胞表现出显著更高的 TGF-β1、COX-2、VEGF、ER-1α、AR 和芳香酶 mRNA 水平，而 PR mRNA 水平显著降低。
结论
子宫内膜异位症和 EOC 细胞中 TGF-β1、COX-2、VEGF、ER-1α、AR 和芳香酶的增加以及 PR 的减少表明这两种疾病过程之间存在潜在的关联。这种关联很重要，因为它可能揭示了这两种疾病的共同机制。
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