Department of Histology and Embryology, Faculty of Medicine, Charles University, Pilsen, Czech Republic.
Department of Obstetrics and Gynecology, University Hospital, Faculty of Medicine, Charles University, Pilsen, Czech Republic.
Reprod Sci. 2022 Jun;29(6):1667-1673. doi: 10.1007/s43032-021-00668-2. Epub 2021 Jun 22.
Endometriosis is a complex and chronic estrogen-dependent disease, affecting a significant proportion of women of reproductive age. Despite the long interest and extensive research, the pathogenesis of the disease is still debated. Although available non-invasive diagnostic methods have adequate accuracy, an invasive approach by laparoscopy is often necessary to obtain histological confirmation. In this scenario, the search for an accurate, reliable, cost-effective, clinically applicable non-invasive biomarker plays a crucial role in a potentially early diagnosis and, in this way, shape the future management of the disease. Considering these elements, the current review aims to summarize the most significant and novel results about biomarkers for the diagnosis and follow-up of women affected by endometriosis.
子宫内膜异位症是一种复杂且慢性的雌激素依赖性疾病，影响着相当一部分育龄期妇女。尽管人们对此一直很感兴趣并进行了广泛的研究，但该疾病的发病机制仍存在争议。虽然现有的非侵入性诊断方法具有足够的准确性，但通常需要通过腹腔镜检查进行侵入性方法以获得组织学确认。在这种情况下，寻找一种准确、可靠、具有成本效益且适用于临床的非侵入性生物标志物对于潜在的早期诊断起着至关重要的作用，并且可以以此来改变该疾病的未来管理方式。考虑到这些因素，本综述旨在总结有关生物标志物用于诊断和随访子宫内膜异位症患者的最显著和最新的结果。
