Bleedorn Jason A, Greuel Erin N, Manley Paul A, Schaefer Susan L, Markel Mark D, Holzman Gerianne, Muir Peter
Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Vet Surg. 2011 Jul;40(5):531-43. doi: 10.1111/j.1532-950X.2011.00841.x. Epub 2011 May 25.
To evaluate stifle joints of dogs for synovitis, before development of joint instability and cranial cruciate ligament rupture (CrCLR).
Cross-sectional study.
Dogs (n = 16) with CrCLR and stable contralateral stifles; 10 control dogs with intact CrCL.
Arthritis and tibial translation were graded radiographically. Synovitis severity and cruciate pathology were assessed arthroscopically. Presence of inflammatory cells in synovial membrane biopsies was scored histologically. CrCLR stifle pairs and control stifles were compared.
Radiographic evidence of arthritis, cranial tibial translation, and arthroscopic synovitis were increased in unstable stifles, when compared with stable contralateral stifles in CrCLR dogs (P < .05). Arthroscopic synovitis in both joints of CrCLR dogs was increased compared with controls, was correlated with radiographic arthritis (S(R) = 0.71, P < .05), and was present in all stable contralateral stifles. Arthroscopically, 75% of stable stifle joints had CrCL fiber disruption, which correlated with severity of synovitis (S(R) = 0.56, P < .05). Histologic evidence of synovitis was identified in all CrCLR dogs, but was only significantly correlated with arthroscopic observations in stable stifles (r(2) = 0.57, P < .005).
Synovitis is an early feature of the CrCLR arthropathy in dogs before development of joint instability clinically. Severity of synovitis is correlated with radiographic arthritis in joints with minimal to no clinically detectable CrCL damage.
在犬关节不稳定和颅侧交叉韧带断裂（CrCLR）发生之前，评估犬的 stifle 关节是否存在滑膜炎。
横断面研究。
患有 CrCLR 且对侧 stifle 关节稳定的犬（n = 16）；10 只 CrCL 完整的对照犬。
通过 X 线片对关节炎和胫骨平移进行分级。通过关节镜评估滑膜炎的严重程度和交叉韧带病变。对滑膜活检组织中的炎症细胞进行组织学评分。比较 CrCLR 关节对和对照关节。
与 CrCLR 犬对侧稳定的 stifle 关节相比，不稳定的 stifle 关节在 X 线片上关节炎、胫骨向前平移及关节镜下滑膜炎的证据增加（P <.05）。与对照组相比，CrCLR 犬双侧关节的关节镜下滑膜炎均增加，与 X 线片上的关节炎相关（S(R) = 0.71，P <.05），且在所有对侧稳定的 stifle 关节中均存在。关节镜检查发现，75%的稳定 stifle 关节存在 CrCL 纤维断裂，这与滑膜炎的严重程度相关（S(R) = 0.56，P <.05）。在所有 CrCLR 犬中均发现滑膜炎的组织学证据，但仅与稳定 stifle 关节的关节镜观察结果显著相关（r(2) = 0.57，P <.005）。
滑膜炎是犬 CrCLR 关节病在临床上出现关节不稳定之前的早期特征。在临床上 CrCL 损伤最小或无损伤的关节中，滑膜炎的严重程度与 X 线片上的关节炎相关。
