Morelli M, Di Chiara G
Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.
Psychopharmacology (Berl). 1990;101(2):287-8. doi: 10.1007/BF02244143.
In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-D-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (-) MK 801 was without effect. The results indicate that the N-methyl-D-aspartate receptor exerts a permissive role on priming.
在单侧用6-羟基多巴胺损伤的大鼠中，D-1激动剂SKF 38393（3毫克/千克，皮下注射）仅在先用多巴胺能激动剂如阿扑吗啡引发后才诱导对侧旋转。在阿扑吗啡（0.1毫克/千克，皮下注射）前15分钟给予N-甲基-D-天冬氨酸受体拮抗剂（+）MK 801（0.1毫克/千克，腹腔注射）可阻止阿扑吗啡作为引发剂的能力，同时增强其急性对侧旋转作用。无活性异构体（-）MK 801则无作用。结果表明，N-甲基-D-天冬氨酸受体在引发过程中发挥允许作用。
