年龄对单侧肾切除术后生长和功能代偿反应的影响。
Influence of age on the compensatory response in growth and function to unilateral nephrectomy.
作者信息
Galla J H, Klein-Robbenhaar T, Hayslett J P
出版信息
Yale J Biol Med. 1974 Dec;47(4):218-26.
The effect of age on the structural and functional response to unilateral nephrectomy was studied in weanling (group I) and young adult (group II) rats. Although compensatory growth in group I was not significantly greater than in group II one week following surgery (44% vs 39%, p - NS), after 4 wk renal mass had increased 144% in group I and 66% in group II (p < .0001). Glomerular filtration rate per unit kidney mass at 1 wk post surgery was 875 ± 92 (mean ± SEM) μ1/min/gKW) in group I and 1132 ± 67 in group II (p - NS) and at 4 wk was 1176 ± 67 in group I and 1261 ± 67 in group II (p - NS). These data indicate that the magnitude of compensatory growth in immature rats is greater than in adults and that functional adaptation parallels the structural change.
在断奶大鼠（I组）和年轻成年大鼠（II组）中研究了年龄对单侧肾切除术后结构和功能反应的影响。虽然术后1周I组的代偿性生长并不显著高于II组（44%对39%，p无统计学意义），但4周后I组肾质量增加了144%，II组增加了66%（p<0.0001）。术后1周，I组每克肾组织的肾小球滤过率为875±92（平均值±标准误）μl/min/gKW，II组为1132±67（p无统计学意义）；4周时，I组为1176±67，II组为1261±67（p无统计学意义）。这些数据表明，未成熟大鼠的代偿性生长幅度大于成年大鼠，且功能适应与结构变化平行。
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