Cardiology Service, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Argentina.
Anim Reprod Sci. 2011 Jun;126(1-2):130-5. doi: 10.1016/j.anireprosci.2011.04.016. Epub 2011 May 4.
The aim of this study was to describe the changes of uterine artery, umbilical artery and fetal abdominal aorta, renal and internal carotid arteries blood flow in abnormal canine pregnancy. Twenty-two, Brucella-negative pregnant bitches were retrospectively classified into abnormal (which had either interrupted their pregnancy between days 52 and 60 or had perinatal death >60% of the litter; n=11) and normal (which had delivered healthy puppies at term; n=11). In all the animals, color and pulsed-wave Doppler examinations of uterine artery were conducted every 10 days from Day 20 to 50 from estimated luteinizing hormone peak. Doppler ultrasonography was also conducted in the fetuses to assess umbilical artery, abdominal aorta, renal and internal carotid arteries from Day 40 to 60 of gestation. Throughout the study, resistance index (RI) of uterine, umbilical and fetal renal arteries decreased up to -15% compared to -36% (P<0.01), -11% compared to -23% (P<0.05) and 2% compared to -13% (P<0.05), respectively in the abnormal and normal bitches. Fetal abdominal aorta and internal carotid did not differ between groups (P>0.05). It is concluded that in dogs, uterine artery, umbilical artery and fetal renal artery RI differ between normal and abnormal gestation being useful for the prediction of adverse obstetric outcome.
本研究旨在描述异常犬妊娠中子宫动脉、脐动脉和胎儿腹主动脉、肾和颈内动脉血流的变化。22 只布鲁氏菌阴性妊娠母犬回顾性分为异常组（妊娠在第 52-60 天中断或产仔死亡率>60%；n=11）和正常组（足月分娩健康幼犬；n=11）。在所有动物中，从估计促黄体激素峰的第 20 天到第 50 天，每隔 10 天对子宫动脉进行彩色和脉冲波多普勒检查。从妊娠第 40 天到第 60 天，还对胎儿进行多普勒超声检查，以评估脐动脉、腹主动脉、肾和颈内动脉。在整个研究过程中，与正常犬相比，异常犬的子宫、脐和胎儿肾动脉的阻力指数（RI）分别下降了-15%（P<0.01）、-11%（P<0.05）和 2%（P<0.05）至-36%、-23%和-13%。胎儿腹主动脉和颈内动脉在两组之间无差异（P>0.05）。综上所述，在犬中，正常和异常妊娠的子宫动脉、脐动脉和胎儿肾动脉 RI 不同，可用于预测不良产科结局。
