Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
Arch Pharm (Weinheim). 2011 Jul;344(7):442-50. doi: 10.1002/ardp.201000341. Epub 2011 May 25.
The reaction of nucleophilic phosphacumulene and phosphallene ylides with different chromenone derivatives was investigated. Heterocycles and carbocycles of various ring sizes and heteroatom patterns such as pyrano-, oxaphosphino-, cyclopenta-, phosphoranylidene cyclobutane-, and phospholo-chromenones were obtained. The antitumor (breast and liver) properties of some new compounds were performed in vitro. Some of these compounds were more potent than the comparative standard.
研究了亲核膦Cumulene 和膦烯叶立德与不同色烯酮衍生物的反应。得到了各种环大小和杂原子模式的杂环和碳环，如吡喃、氧膦、环戊、磷亚基环丁烷和磷杂环戊烯酮色烯酮。一些新化合物的体外抗肿瘤（乳腺和肝脏）性质进行了研究。其中一些化合物比比较标准更有效。
