Ryan Matthew W
Department of Otolaryngology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9035, USA.
Otolaryngol Clin North Am. 2011 Jun;44(3):697-710, ix-x. doi: 10.1016/j.otc.2011.03.015. Epub 2011 May 2.
Allergic fungal rhinosinusitis is a phenotype of chronic rhinosinusitis with nasal polyposis, characterized by type 1 hypersensitivity to fungi, eosinophilic mucin with fungal hyphae in sinus secretions, and propensity for mucocele formation and bone erosion. Although its differentiation from other forms of chronic polypoid rhinosinusitis with eosinophilic mucin is sometimes problematic, type 1 hypersensitivity is a component of the disease process. Medical and surgical management can be augmented by immunotherapy directed toward the patient's specific allergen sensitivities. The primary rationale for immunotherapy is to control the allergic diathesis that may be contributing to the patient's chronic sinus inflammation.
变应性真菌性鼻-鼻窦炎是慢性鼻-鼻窦炎伴鼻息肉的一种表型，其特征为对真菌的1型超敏反应、鼻窦分泌物中含有真菌菌丝的嗜酸性黏液，以及形成黏液囊肿和骨质侵蚀的倾向。尽管有时难以将其与其他伴有嗜酸性黏液的慢性息肉样鼻-鼻窦炎相鉴别，但1型超敏反应是疾病过程的一个组成部分。针对患者特定变应原敏感性的免疫疗法可增强药物和手术治疗效果。免疫疗法的主要原理是控制可能导致患者慢性鼻窦炎症的变应素质。
