I期非精原细胞性睾丸生殖细胞肿瘤的组织病理学特征与复发相关。丹麦睾丸癌研究组。

Histopathological features in stage I non-seminomatous testicular germ cell tumours correlated to relapse. Danish Testicular Cancer Study Group.

作者信息

Jacobsen G K, Rørth M, Osterlind K, von der Maase H, Jacobsen A, Madsen E L, Pedersen M, Schultz H

机构信息

Department of Oncology, Finsen Institute, Herlev, Odense.

出版信息

APMIS. 1990 Apr;98(4):377-82. doi: 10.1111/j.1699-0463.1990.tb01047.x.

DOI:10.1111/j.1699-0463.1990.tb01047.x

PMID:2162186

Abstract

156 patients with stage I non-seminomatous testicular germ cell tumour entered a countrywide randomized study comparing the effect of postoperative irradiation of retroperitoneal lymph nodes with surveillance only. A total of 150 patients were included in this investigation of factors associated with increased risk of relapse. Thirty-four patients (23 per cent) had a relapse, i.e. 11/67 (16 per cent) in the former and 23/83 (28 per cent) in the latter group. Histopathological studies of the orchidectomy specimens were performed in order to identify features associated with relapse. Pure embryonal carcinoma and vascular involvement were significantly associated with increased risk of relapse. Thus, the relapse rate in the observation group in patients with pure embryonal carcinomas was 50 per cent (5/10) and 36 per cent (19/53) in all patients with tumours with vascular involvement.

摘要

156例I期非精原细胞性睾丸生殖细胞瘤患者进入一项全国性随机研究，比较腹膜后淋巴结术后放疗与单纯监测的效果。本研究共纳入150例与复发风险增加相关因素的患者。34例患者（23%）出现复发，即前一组11/67例（16%），后一组23/83例（28%）。对睾丸切除标本进行组织病理学研究，以确定与复发相关的特征。单纯胚胎癌和血管受累与复发风险增加显著相关。因此，单纯胚胎癌患者观察组的复发率为50%（5/10），所有有血管受累肿瘤患者的复发率为36%（19/53）。