Division of Nephrology/Hypertension, Feinberg School of Medicine, Northwestern University, IL, USA.
Front Biosci (Landmark Ed). 2011 Jun 1;16(7):2756-70. doi: 10.2741/3884.
The Receptor for Advanced Glycation End-products (RAGE) is a complex, multi-ligand signaling system implicated in the pathogenesis of diabetes, cardiovascular disease and various cancers. RAGE undergoes extensive alternative splicing to produce a variety of transcripts with diverse functions, including soluble antagonists and variants with altered ligand binding domains. Studies focused on the major soluble variant (RAGEv1/esRAGE) have revealed this to function by binding RAGE-ligands and preventing activation of RAGE signaling in vascular and tumor cells. Furthermore, measurement of this variant in human serum has revealed that RAGEv1/esRAGE levels may represent a novel biomarker for RAGE-ligand related pathogenic states. Understanding the full plethora of RAGE alternative splicing and its regulation is central to elucidating the role of RAGE in biology and disease.
晚期糖基化终产物受体（RAGE）是一种复杂的多配体信号系统，与糖尿病、心血管疾病和各种癌症的发病机制有关。RAGE 通过广泛的选择性剪接产生具有多种功能的各种转录本，包括可溶性拮抗剂和改变配体结合域的变体。针对主要可溶性变体（RAGEv1/esRAGE）的研究表明，它通过与 RAGE 配体结合并防止血管和肿瘤细胞中 RAGE 信号的激活来发挥作用。此外，在人血清中测量这种变体表明，RAGEv1/esRAGE 水平可能代表与 RAGE 配体相关致病状态的新型生物标志物。了解 RAGE 选择性剪接的全貌及其调控是阐明 RAGE 在生物学和疾病中的作用的核心。
