Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
Molecules. 2011 May 27;16(6):4500-10. doi: 10.3390/molecules16064500.
A clean, practical and environmentally friendly synthesis in a homogeneous system has been developed for α-oxoketene S,S-acetals. A mixture of [Bmim]Cl and water was used as medium. The best economical and practical molar ratio of [Bmim]Cl to substrate was 4 to 1. With various types of 1,3-dicarbonyl compounds as substrate, the corresponding α-oxoketene S,S-acetals have been prepared under mild reaction conditions with yields of 53-74% after purification with silica gel column. [Bmim]Cl/water can be recycled several times.
已经开发出一种在均相体系中清洁、实用且环保的α-氧代烯酮 S，S-缩醛合成方法。该方法使用[Bmim]Cl 和水的混合物作为介质。[Bmim]Cl 与底物的最佳经济实用摩尔比为 4:1。以各种类型的 1,3-二羰基化合物作为底物，在温和的反应条件下，通过硅胶柱纯化后，得到相应的α-氧代烯酮 S，S-缩醛，产率为 53-74%。[Bmim]Cl/水可以多次回收利用。
