Collier A C, Handsfield H H, Roberts P L, DeRouen T, Meyers J D, Leach L, Murphy V L, Verdon M, Corey L
Department of Medicine and Laboratory Medicine, School of Medicine, University of Washington, Seattle.
J Infect Dis. 1990 Jul;162(1):46-51. doi: 10.1093/infdis/162.1.46.
To evaluate prospectively the relationship between current and past sexual practices and seroprevalence of cytomegalovirus (CMV) in adult women, 1481 women (1101 white, 301 black, 79 other) attending a sexually transmitted disease clinic underwent a standardized interview and genital examination. CMV seroprevalence was higher in black (78%) than in white (59%) women. In logistic regression models that adjusted for age and years of education, CMV seropositivity in white women was associated with younger sexual debut (P = .001), more lifetime sex partners (P = .025), recent new partner(s) (P = .003), and parity (P = .002), and was inversely associated with use of barrier contraception (P = .006). In black women, after adjustment for demographic characteristics, CMV antibody was associated with greater numbers of recent sex partners (P = .007), new sex partners (P = .04), and with cervical infection with Chlamydia trachomatis (P = .05). This study confirms that sexual activity is an important determinant of CMV infection in both white and black women; however, the relative contributions of sexual and nonsexual transmission of CMV apparently vary and require further investigation.
为前瞻性评估成年女性当前及既往性行为与巨细胞病毒（CMV）血清阳性率之间的关系，1481名就诊于性传播疾病诊所的女性（1101名白人、301名黑人、79名其他种族）接受了标准化访谈及生殖器检查。黑人女性的CMV血清阳性率（78%）高于白人女性（59%）。在对年龄和受教育年限进行校正的逻辑回归模型中，白人女性的CMV血清阳性与初次性行为年龄较小（P = .001）、性伴侣数量较多（P = .025）、近期有新性伴侣（P = .003）以及生育情况（P = .002）相关，且与使用屏障避孕措施呈负相关（P = .006）。在黑人女性中，校正人口统计学特征后，CMV抗体与近期性伴侣数量较多（P = .007）、新性伴侣（P = .04）以及沙眼衣原体宫颈感染相关（P = .05）。本研究证实，性行为是白人及黑人女性CMV感染的重要决定因素；然而，CMV性传播和非性传播的相对作用显然有所不同，需要进一步研究。
