Plasma exchange: a treatment for neuropathy associated with IgG-kappa gammopathy.

A patient with a peripheral neuropathy associated with an IgG-kappa gammopathy is reported who was treated with plasma exchange as the only therapeutic modality and showed dramatic clinical improvement, which fluctuated based on the frequency of plasma exchange. Therapeutic plasma exchange is recommended as one form of possible treatment for neuropathies resulting from IgG gammopathies. The literature is reviewed.